Involucrin expression in keratinization disorders of the skin--a preliminary study.

Abstract

We have studied the expression of involucrin in a variety of keratinization disorders, mostly of genetic origin using an avidin-biotin-peroxidase technique. In normal human epidermis 25% of the living epidermis was labelled. The diseases studied fell into two groups. Diseases with greatly increased involucrin staining including collodion baby (38%), Darier's disease (49%), Flegel's disease (56%), erythrokeratoderma variabilis (60%), epidermal naevus with epidermolytic hyperkeratosis (45%) and congenital bullous (58%) and non-bullous (44%) ichythyosiform erythroderma; and diseases with normal or slightly increased staining, including ichthyosis vulgaris (27%), X-linked ichthyosis (25%), confluent and reticulate papillomatosis (27%) and simple epidermal naevus (28%). These results demonstrate that involucrin expression is altered in some keratinization disorders and suggest that in such conditions cellular functions other than keratin metabolism are also affected.

• Authors: J Kanitakis, G Zambruno, J Viac, J Thivolet
• Journal: The British journal of dermatology (Br J Dermatol) Vol. 117 Issue 4 Pg. 479-86 (Oct 1987) ISSN: 0007-0963 [Print] England
• PMID: 3676094 (Publication Type: Journal Article)

Chemical References

• Protein Precursors
• involucrin

Topics

• Humans
• Keratosis (metabolism, pathology)
• Protein Precursors (metabolism)
• Skin (metabolism, pathology)