Abstract |
We have studied the influence of different degrees of calorie restriction on the induction and the regulation of the delayed type hypersensitivity (DTH) response to trinitrobenzenesulfonic acid (TNBS) and TNBS-modified spleen cells (TNBS-SC), injected by the sc or the iv route. Immediately after weaning, BALB/c mice were placed on restricted diets for either 2 or 4 weeks and then the DTH response was induced. The results showed that a 37.5% restriction in the food supply significantly depressed the level of the DTH response induced by the sc injection of TNBS-SC. In contrast, a 25% restriction in the food supply was insufficient to depress the response. Calorie restriction did not modify the inhibitory influence of an iv injection of TNBS-SC on the DTH response. However, iv presensitization with free hapten or the simultaneous injection of TNBS-SC by the iv and the sc routes did not significantly depress the DTH response in calorie-restricted mice, indicating a defect in the inhibitory regulation of the DTH response in these dietary groups.
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Authors | M Pocino, L Baute, I Malavé |
Journal | Cellular immunology
(Cell Immunol)
Vol. 109
Issue 2
Pg. 261-71
(Oct 15 1987)
ISSN: 0008-8749 [Print] Netherlands |
PMID | 3664643
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Haptens
- Nitrobenzenes
- Trinitrobenzenesulfonic Acid
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Topics |
- Animals
- Body Weight
- Diet, Reducing
- Female
- Haptens
- Hypersensitivity, Delayed
- Immunization
- Lymphocytes
(immunology)
- Male
- Mice
- Mice, Inbred BALB C
- Nitrobenzenes
- Spleen
(immunology)
- Time Factors
- Trinitrobenzenesulfonic Acid
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