Biochemical studies on bilharzial and nonbilharzial hyperoxaluria: effect of pyridoxine and allopurinol treatment.

Abstract

The urinary excretion levels of oxalic acid, calcium, kynurenic, and xanthurenic acids and serum pyridoxal and pyridoxal phosphate concentrations were determined for nonbilharzial and bilharzial hyperoxaluric patients with or without urinary stones. The effects of pyridoxine and allopurinol treatment were also studied. The different groups studied showed elevated levels of urinary oxalic acid, calcium, kynurenic, and xanthurenic acids as well as decreases in serum pyridoxal and pyridoxal phosphate concentrations. These data indicate that nonbilharzial hyperoxaluric patients suffer from dietary B6 deficiency, whereas bilharzial hyperoxaluric patients may suffer from impaired pyridoxine phosphokinase activity. Pyridoxine supplementation is recommended for the treatment of nonbilharzial hyperoxaluric patients. Allopurinol may be the proper drug in the treatment of oxaluria and stone formation or of bilharzial patients.

• Authors: A E el-Habet, S M el-Sewedy, A el-Sharaky, N K Gaafar, A Abdel-Rafee, F Hamoud
• Journal: Biochemical medicine and metabolic biology (Biochem Med Metab Biol) Vol. 38 Issue 1 Pg. 1-8 (Aug 1987) ISSN: 0885-4505 [Print] United States
• PMID: 3663392 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Oxalates
• Allopurinol
• Urea
• Creatinine
• Aspartate Aminotransferases
• Alanine Transaminase
• Alkaline Phosphatase
• Pyridoxine
• Calcium

Topics

• Adult
• Alanine Transaminase (blood)
• Alkaline Phosphatase (blood)
• Allopurinol (therapeutic use)
• Aspartate Aminotransferases (blood)
• Calcium (urine)
• Creatinine (blood)
• Humans
• Male
• Middle Aged
• Oxalates (urine)
• Pyridoxine (therapeutic use)
• Reference Values
• Schistosomiasis (blood, complications, urine)
• Urea (blood)
• Urinary Calculi (blood, drug therapy, urine)