Abstract |
To assess the clinical and serological outcome of hepatitis delta virus (HDV) infection, 59 patients with acute delta hepatitis were followed for 6-28 months. Forty-two patients had simultaneous HDV and HBV coinfection (anti-HBc IgM-positive, group I) and 17 were HBsAg carriers with HDV superinfection (anti-HBc IgM-negative, group II). Overall, serum HD-Ag and anti-HD IgM were the most sensitive markers for diagnosis of delta infection during the first 2 weeks after onset of symptoms. The clinical presentation was similar in both groups; 4 patients (1 in group I and 3 in group II) (7%) developed fulminant hepatitis, but none of them died. The majority of patients with HBV-HDV coinfection (group I) eventually recovered, whereas all HBsAg carriers with HDV superinfection (group II) developed chronic liver disease. Liver histology in these patients showed chronic active hepatitis and/or cirrhosis in 90%. The hepatic lesion was probably due to persistent HDV infection, as indicated by the presence of intrahepatic HD-Ag and/or persistence of serum anti-HD IgM in 90% of the patients.
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Authors | M Buti, R Estebán, R Jardi, H Allende, J I Estebán, J Genesca, J Guardia |
Journal | Journal of hepatology
(J Hepatol)
Vol. 5
Issue 1
Pg. 59-64
(Aug 1987)
ISSN: 0168-8278 [Print] Netherlands |
PMID | 3655311
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Viral
- Antigens, Viral
- Hepatitis B Surface Antigens
- Immunoglobulin M
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Topics |
- Antibodies, Viral
(analysis)
- Antigens, Viral
(analysis)
- Hepatitis B
(complications)
- Hepatitis B Surface Antigens
(analysis)
- Hepatitis D
(complications, pathology, physiopathology)
- Hepatitis Delta Virus
(immunology)
- Hepatitis, Chronic
(complications)
- Humans
- Immunoglobulin M
(analysis)
- Liver
(pathology)
- Liver Cirrhosis
(complications)
- Prospective Studies
- Time Factors
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