Abstract |
The acute haemodynamic effects of taurine were studied in normal and in beta blocker ( propranolol) or calcium antagonist ( diltiazem) treated rabbits and in rabbits with experimentally produced chronic aortic regurgitation. The administration of taurine (25 mg.kg-1) did not affect heart rate and left ventricular end diastolic pressure but produced significant increases in left ventricular dP/dtmax, cardiac output, and left ventricular systolic pressure in control hearts, indicating that intravascularly administered taurine substantially increased cardiac performance. In propranolol (1 mg.kg-1) treated rabbits taurine significantly improved left ventricular dP/dtmax and cardiac output, which were previously depressed by propranolol. Taurine had the same effect on diltiazem (1 mg.kg-1) treated rabbits. In rabbits with aortic regurgitation a bolus injection of taurine improved cardiac performance. Continuous infusion of taurine (100 mg.h-1) also produced a significant increase in left ventricular dP/dtmax. These results suggest that taurine has a unique action as an inotropic agent and that it may be useful in the treatment of patients with congestive heart failure.
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Authors | N Awata, J Azuma, T Hamaguchi, Y Tanaka, H Ohta, K Takihara, H Harada, A Sawamura, S Kishimoto |
Journal | Cardiovascular research
(Cardiovasc Res)
Vol. 21
Issue 4
Pg. 241-7
(Apr 1987)
ISSN: 0008-6363 [Print] England |
PMID | 3652090
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Taurine
- Propranolol
- Diltiazem
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Topics |
- Animals
- Aortic Valve Insufficiency
(physiopathology)
- Cardiac Output
(drug effects)
- Diltiazem
(pharmacology)
- Heart
(drug effects)
- Heart Rate
(drug effects)
- Propranolol
(pharmacology)
- Rabbits
- Taurine
(pharmacology)
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