Effects of kallikrein on the male reproductive system and its use in the treatment of idiopathic oligozoospermia with impaired motility.

Abstract

A single-blind study on the effects of kallikrein in idiopathic oligozoospermia was carried out. 8 of the 16 patients admitted to the trial were treated with kallikrein 100 K.U. t.i.d., the remaining patients received vitamin E 100 mg t.i.d. Treatment lasted 120 days in both groups. Kallikrein led to an increase in sperm concentration, total sperm count and sperm penetration capacity. Patients receiving vitamin E failed to show any improvement. It is postulated that the increase in sperm concentration could be explained by the positive action of kallikrein on spermatogenesis, due to a stimulatory effect of the drug directly on the Sertoli cell function and on the circulation in the vascular system of the testis.

• Authors: P Giovenco, M Amodei, C Barbieri, R Fasani, M Carosi, F Dondero
• Journal: Andrologia (Andrologia) Vol. 19 Spec No Pg. 238-41 (Jun 1987) ISSN: 0303-4569 [Print] Germany
• PMID: 3651109 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Vitamin E
• Kallikreins

Topics

• Animals
• Cattle
• Cervix Mucus
• Female
• Humans
• Kallikreins (metabolism)
• Male
• Oligospermia (drug therapy)
• Sperm Count
• Sperm Motility (drug effects)
• Spermatogenesis (drug effects)
• Spermatozoa (drug effects, physiology)
• Testis (blood supply)
• Vitamin E (therapeutic use)