Abstract |
Neuropsychological function was assessed before and after carbamazepine monotherapy in children with newly diagnosed complex partial epilepsy. Simultaneous video-electroencephalographic monitoring examined the influence of subclinical abnormal electrical discharges on performance. Total and unbound plasma carbamazepine concentrations were examined in relation to changes in performance at low ( carbamazepine level, less than or equal to 32 mumol/L [less than or equal to 7.5 mg/L]) and moderate ( carbamazepine level, greater than 34 mumol/L [greater than 8.0 mg/L]) drug levels. The data suggest a mild beneficial effect of carbamazepine on speeded eye-hand coordination and, at low drug levels, more rapid processing of items in memory. Efficiency of learning new information and memory-scanning rate displayed a concentration-dependent relationship with carbamazepine level, with poor performance significantly associated with higher carbamazepine plasma concentrations. Carbamazepine free levels were equivalent to total levels in predicting cognitive side effects.
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Authors | M O'Dougherty, F S Wright, S Cox, P Walson |
Journal | Archives of neurology
(Arch Neurol)
Vol. 44
Issue 8
Pg. 863-7
(Aug 1987)
ISSN: 0003-9942 [Print] United States |
PMID | 3632397
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Carbamazepine
(administration & dosage, adverse effects, blood)
- Child
- Cognition Disorders
(chemically induced, diagnosis)
- Electroencephalography
- Epilepsy, Temporal Lobe
(drug therapy)
- Female
- Humans
- Learning
(drug effects)
- Male
- Memory
(drug effects)
- Monitoring, Physiologic
- Neuropsychological Tests
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