Oral gentamicin therapy in the prevention of neonatal necrotizing enterocolitis. A controlled double-blind trial.

Abstract

The value of prophylactic oral gentamicin sulfate therapy in the prevention of necrotizing enterocolitis (NEC) was evaluated in a group of 42 high-risk neonates over a four-month period in a randomized, double-blind controlled trial. Twenty babies in the treatment group received 2.5 mg/kg of gentamicin sulfate every six hours for one week after birth, and 22 babies received dextrose-and-water placebo in an equivalently small volume. None of the 20 gentamicin-treated babies developed NEC. Four of the control babies did. Two of these babies died, and their diagnosis was pathologically confirmed. This difference in the incidence of NEC between the treatment and control group was significant at the .05 level. These results support the prophylactic use of orally given gentamicin for selected babies at high risk for NEC, particularly those born prematurely and those who have a history of perinatal asphyxia or umbilical artery catheterization or both. Continued surveillance for changes in antimicrobial sensitivity patterns is recommended.

• Authors: L J Grylack, J W Scanlon
• Journal: American journal of diseases of children (1960) (Am J Dis Child) Vol. 132 Issue 12 Pg. 1192-4 (Dec 1978) ISSN: 0002-922X [Print] United States
• PMID: 362900 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Gentamicins
• Placebos

Topics

• Administration, Oral
• Clinical Trials as Topic
• Double-Blind Method
• Enterocolitis, Pseudomembranous (prevention & control)
• Gentamicins (administration & dosage)
• Humans
• Infant, Low Birth Weight
• Infant, Newborn
• Infant, Newborn, Diseases (prevention & control)
• Infant, Premature, Diseases (prevention & control)
• Placebos
• Prospective Studies