Abstract |
Circadian periodicity of plasma 17-hydroxycorticosteroids (17-OHCS) was studied in ten patients with advanced breast cancer and ten healthy volunteers. A marked rhythm in plasma 17-OHCS concentration was noticed in normal controls; the maximum concentration occurred at 0800 hr followed by a consistent decline throughout the daytime, reaching a minimum at 0000 hr. The circadian rhythm of plasma 17-OHCS was found to be deranged in six of the patients with breast cancer, but a normal rhythmic pattern was seen in the remaining four patients, although the values remained elevated at all time points of the 24-hr cycle in the patients with breast cancer compared to the healthy volunteers. The normal and altered plasma 17-OHCS rhythms in the patients presumably could be due to individual susceptibility and response to the pathophysiological stress of cancer.
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Authors | R K Singh, S Singh, J L Razdan |
Journal | Progress in clinical and biological research
(Prog Clin Biol Res)
Vol. 227B
Pg. 335-42
( 1987)
ISSN: 0361-7742 [Print] United States |
PMID | 3628346
(Publication Type: Journal Article)
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Chemical References |
- 17-Hydroxycorticosteroids
|
Topics |
- 17-Hydroxycorticosteroids
(blood)
- Adult
- Breast Neoplasms
(blood)
- Circadian Rhythm
- Female
- Humans
- Middle Aged
- Stress, Physiological
(blood)
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