Demonstration of growth-inhibitory as well as growth-stimulatory factors in medium conditioned by lung lavage cells stimulated with a chemotactic factor secreted by jaagsiekte tumour cells.

Both growth-inhibitory and growth-stimulatory factors were detected in vitro in medium from chemotactically stimulated cultures of lung lavage cells. The macrophage component of the lavage cells was found to produce a growth stimulatory factor that was replaced by a growth inhibitory factor following chemotactic factor stimulation.
AuthorsM S Myer, D W Verwoerd, H M Garnett
JournalThe Onderstepoort journal of veterinary research (Onderstepoort J Vet Res) Vol. 54 Issue 2 Pg. 123-30 (Jun 1987) ISSN: 0030-2465 [Print] SOUTH AFRICA
PMID3627727 (Publication Type: Journal Article)
Chemical References
  • Chemotactic Factors
  • Growth Inhibitors
  • Growth Substances
  • Animals
  • Cells, Cultured
  • Chemotactic Factors (secretion)
  • Growth Inhibitors (secretion)
  • Growth Substances (biosynthesis)
  • Macrophages
  • Pulmonary Adenomatosis, Ovine (metabolism)
  • Pulmonary Alveoli (pathology)
  • Sheep

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