HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Case report: Incidentally discovered case of pheochromocytoma as a cause of long COVID-19 syndrome.

Abstract
Pheochromocytomas (PCCs) are rare but potentially lethal tumors that arise from the adrenal medulla. The clinical suspicion and diagnosis of PCC can be challenging due to the non-specific nature of signs and symptoms. In many patients, infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could lead to long-term symptoms including fatigue, headaches, and cognitive dysfunction. Here, we present the case of a patient incidentally diagnosed with an adrenal mass that proved to be a PCC after imaging was performed due to persisting complaints after coronavirus disease 2019 (COVID-19) infection. A 37-year-old male patient was referred to our center because of a right-sided inhomogeneous adrenal mass, incidentally found during a computed tomographic scan of the thorax performed due to cough and dyspnea that persisted after COVID-19 infection. Other complaints that were present prior to COVID-19 infection included profuse sweating, dizziness, exhaustion with chronic fatigue, and concentration difficulties. The patient had no history of hypertension, his blood pressure was normal, and the 24-h ambulatory blood pressure monitoring confirmed normotension but with the absence of nocturnal dipping. Plasma normetanephrine was 5.7-fold above the upper limit (UL) of reference intervals (738 pg/ml, UL = 129 pg/ml), whereas plasma metanephrine and methoxytyramine were normal at 30 pg/ml (UL = 84 pg/ml) and <4 pg/ml (UL = 16 pg/ml), respectively. Preoperative preparation with phenoxybenzamine was initiated, and a 4-cm tumor was surgically resected. Profuse sweating as well as dizziness was resolved after adrenalectomy pointing toward PCC and not COVID-19-associated patient concerns. Altogether, this case illustrates the difficulties in recognizing the possibility of PCC due to the non-specific nature of signs and symptoms of the tumor, which in this case did not include hypertension and coincided with some of the symptoms of long COVID-19.
AuthorsChristian G Ziegler, Carina Riediger, Matthias Gruber, Carola Kunath, Martin Ullrich, Jens Pietzsch, Svenja Nölting, Timo Siepmann, Stefan R Bornstein, Hanna Remde, Georgiana Constantinescu
JournalFrontiers in endocrinology (Front Endocrinol (Lausanne)) Vol. 13 Pg. 967995 ( 2022) ISSN: 1664-2392 [Print] Switzerland
PMID36237184 (Publication Type: Case Reports, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2022 Ziegler, Riediger, Gruber, Kunath, Ullrich, Pietzsch, Nölting, Siepmann, Bornstein, Remde and Constantinescu.
Chemical References
  • Normetanephrine
  • Phenoxybenzamine
  • Metanephrine
Topics
  • Adrenal Gland Neoplasms (complications, diagnosis, surgery)
  • Adult
  • Blood Pressure Monitoring, Ambulatory
  • COVID-19 (complications)
  • Dizziness (complications)
  • Humans
  • Hypertension (complications)
  • Male
  • Metanephrine
  • Normetanephrine
  • Phenoxybenzamine
  • Pheochromocytoma (complications, diagnosis, surgery)
  • SARS-CoV-2
  • Post-Acute COVID-19 Syndrome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: