Specific effect of estradiol on the genital mucosal antibody response in chlamydial ocular and genital infections.

Abstract

Estradiol treatment of female guinea pigs was found to alter the course of genital, but not ocular, infection with the chlamydial agent of guinea pig inclusion conjunctivitis. Immunoglobulin G (IgG) and IgA responses in genital secretions of genitally infected animals were delayed by estradiol treatment, but neither response in the eye resulting from either ocular or genital infection was affected. However, the appearance of IgG in the genital tract after ocular infection was markedly inhibited in estradiol-treated guinea pigs.

• Authors: R G Rank, A L Barron
• Journal: Infection and immunity (Infect Immun) Vol. 55 Issue 9 Pg. 2317-9 (Sep 1987) ISSN: 0019-9567 [Print] United States
• PMID: 3623706 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antibodies, Bacterial
• Immunoglobulin A
• Immunoglobulin G
• Estradiol

Topics

• Animals
• Antibodies, Bacterial (analysis)
• Antibody Formation (drug effects)
• Chlamydia Infections (immunology)
• Conjunctivitis, Inclusion (immunology)
• Epithelium (immunology)
• Estradiol (pharmacology)
• Eye (immunology)
• Female
• Genital Diseases, Female (immunology)
• Genitalia, Female (immunology)
• Guinea Pigs
• Immunoglobulin A (analysis)
• Immunoglobulin G (analysis)