Treatment of pituitary dwarfism with authentic recombinant human growth hormone (SM-9500).

Abstract

Twenty-one patients with pituitary dwarfism were treated with methionine-free hGH (r-hGH) for 6 months with a dosage of 0.5 IU/kg/week. The height of newly treated patients (N = 14), increased from 2.4 to 5.0 cm during treatment, which corresponded to from 4.8 to 10.0 cm with a mean of 8.1 +/- 0.5 cm/year. In switched patients (N = 7), height increased from 2.2 to 3.8 cm during the treatment, which corresponded to 4.4-7.6 cm with a mean of 6.1 +/- 0.5 cm/year, which was similar to that observed in previous treatment with pituitary extracted hGH (p-hGH). Anti-hGH antibody was observed in two patients (9.5%) at the end of 6 months of treatment with a titer of 10. These data indicate that r-hGH has a growth promoting effect and low antigenicity.

• Authors: K Takano, K Shizume, I Hibi, A Okuno, K Hanyu, S Suwa, H Nakajima, T Kondo, K Kato, N Iwatani
• Journal: Endocrinologia japonica (Endocrinol Jpn) Vol. 34 Issue 2 Pg. 291-7 (Apr 1987) ISSN: 0013-7219 [Print] Japan
• PMID: 3622395 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies
• Hormones
• Recombinant Proteins
• Growth Hormone

Topics

• Adolescent
• Age Determination by Skeleton
• Antibodies (analysis)
• Child
• Dwarfism, Pituitary (drug therapy)
• Female
• Growth Hormone (analogs & derivatives, deficiency, immunology)
• Hormones (therapeutic use)
• Humans
• Male
• Recombinant Proteins (therapeutic use)