Intermittent application of clobetasol-17-propionate in psoriasis.

Abstract

A double-blind study was carried out in 12 hospitalized patients with symmetrical eruptions of psoriasis to evaluate the effectiveness of treatment with 0.05% clobetasol propionate ointment, applied once daily, to one side for 2 weeks compared with 1 week of active treatment and 1 week of vehicle alone to the other side. The results of clinical assessments of scaling, redness, and induration before and after each week of treatment showed only a very slight difference in favour of 2-weeks' continuous treatment when analyzed using a one-tailed Student's t-test (p = 0.047) but not when two-tailed testing was used (p = 0.094). Although it would appear that there was no clear preference for continuous therapy, other studies involving larger numbers of patients are needed to determine whether intermittent therapy with a potent corticosteroid such as clobetasol propionate is equally as effective in psoriasis.

• Authors: E Young, E A van der Velde
• Journal: Current medical research and opinion (Curr Med Res Opin) Vol. 10 Issue 7 Pg. 468-73 ( 1987) ISSN: 0300-7995 [Print] England
• PMID: 3621992 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Betamethasone
• Clobetasol

Topics

• Administration, Cutaneous
• Adult
• Aged
• Aged, 80 and over
• Betamethasone (analogs & derivatives)
• Clobetasol (administration & dosage, analogs & derivatives)
• Double-Blind Method
• Drug Administration Schedule
• Drug Evaluation
• Female
• Humans
• Male
• Middle Aged
• Psoriasis (drug therapy)
• Random Allocation