Convulsions as the etiology of lactic acidosis in acute diazinon toxicity in rats.

Abstract

Diazinon, in acute doses (40 mg/kg, i.p.) in rats produced tremors and convulsions with lactic acidosis which was accompanied by depletion of glycogen and activation of glycogen phosphorylase activity in triceps and diaphragm muscles, 2 h after its administration. Prevention of convulsions with phenobarbitone administered immediately before diazinon, resulted in neither the development of lactic acidosis nor mobilization of muscle glycogen or activation of glycogen phosphorylase. Lactic acidosis was due to depletion of glycogen through enhanced activity of glycogen phosphorylase in muscles on account of tremors and convulsions induced by diazinon in rats.

• Authors: K Husain, M A Mirza, M A Matin
• Journal: Toxicology letters (Toxicol Lett) Vol. 37 Issue 3 Pg. 257-61 (Aug 1987) ISSN: 0378-4274 [Print] Netherlands
• PMID: 3617100 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Insecticides
• Lactates
• Lactic Acid
• Glycogen
• Phosphorylases
• Diazinon

Topics

• Acidosis, Lactic (etiology)
• Acute Disease
• Animals
• Diazinon (poisoning)
• Female
• Glycogen (metabolism)
• Insecticides (poisoning)
• Lactates (blood)
• Lactic Acid
• Muscles (metabolism)
• Phosphorylases (metabolism)
• Rats
• Rats, Inbred Strains
• Seizures (chemically induced, complications, metabolism)