Oestrogen and progesterone receptor concentrations in leiomyoma and normal myometrium.

Abstract

The content of cytoplasmic 17 beta oestradiol and progesterone receptors in human uterine leiomyoma and normal myometrium in the Negroid population was determined. Eighteen women of reproductive age, at various stages of the menstrual cycle, were included in the study. The serum oestrogen and progesterone concentrations were also measured. This is the first report in the literature in which oestrogen and progesterone receptors in leiomyoma are significantly higher than in normal myometrium (P = 0.0002). The steroid dependence of the growth of leiomyomas may be related to the steroid receptor level. The presence of persistently high concentrations of oestrogen and progesterone receptors in leiomyoma should be helpful in the treatment of this benign tumour.

• Authors: O Sadan, B van Iddekinge, C J van Gelderen, N Savage, P J Becker, L A van der Walt, M Robinson
• Journal: Annals of clinical biochemistry (Ann Clin Biochem) Vol. 24 ( Pt 3) Pg. 263-7 (May 1987) ISSN: 0004-5632 [Print] England
• PMID: 3606010 (Publication Type: Journal Article)

Chemical References

• Indicators and Reagents
• Receptors, Estrogen
• Receptors, Progesterone
• Progesterone
• Estradiol

Topics

• Adult
• Cytoplasm (metabolism)
• Estradiol (blood)
• Female
• Humans
• Indicators and Reagents
• Leiomyoma (metabolism)
• Menstrual Cycle
• Middle Aged
• Myometrium (metabolism)
• Progesterone (blood)
• Receptors, Estrogen (analysis)
• Receptors, Progesterone (analysis)
• Uterine Neoplasms (metabolism)