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Cardiovascular responses to a newly developed cardiotonic agent, ZSY-39 [4-methyl-5-(4-pyridinyl)-thiazole-2-carboxyamide] in dog cross-circulated atrial and ventricular preparations.

Abstract
The cardiovascular effects of ZSY-39 [4-methyl-5-(4-pyridinyl)-thiazole-2-carboxyamide] were investigated in isolated and blood-perfused atrial and ventricular muscles perfused with donor's arterial blood. When ZSY-39 was given i.v. to the intact donor dog, hypotension with a slight tachycardia was induced at a dose range of 30-1,000 micrograms/kg. At the same time, slight positive chronotropic and inotropic responses appeared in isolated, perfused atria at i.v. doses of 300 and 1,000 micrograms/kg ZSY-39, indicating a relatively dominant inotropic action. Direct injection of ZSY-39 into the cannulated sinus node artery of the isolated atrium produced positive chronotropic and inotropic responses in a dose-related manner (1 to 300 micrograms). ZSY-39 also induced a dose-dependent increase in developed tension in the isolated ventricle. The positive chronotropic and inotropic effects of ZSY-39 were not modified by an adequate dose of propranolol which completely blocked norepinephrine-induced positive chronotropic and inotropic responses. From these results, it is concluded that ZSY-39 has mild cardiotonic properties, showing relatively selective positive inotropic activity.
AuthorsS Chiba, Y Furukawa, K Saegusa, Y Ogiwara, M Takeda
JournalJapanese heart journal (Jpn Heart J) Vol. 28 Issue 2 Pg. 253-60 (Mar 1987) ISSN: 0021-4868 [Print] Japan
PMID3599412 (Publication Type: Journal Article)
Chemical References
  • Cardiotonic Agents
  • Phosphodiesterase Inhibitors
  • Pyridines
  • Thiazoles
  • 4-methyl-5-(4-pyridinyl)thiazole-2-carboxamide
Topics
  • Animals
  • Cardiotonic Agents (pharmacology)
  • Cross Circulation
  • Dogs
  • Dose-Response Relationship, Drug
  • Female
  • Heart (drug effects)
  • Heart Conduction System (drug effects)
  • Heart Rate (drug effects)
  • Hypotension (chemically induced)
  • In Vitro Techniques
  • Male
  • Myocardial Contraction (drug effects)
  • Parabiosis
  • Phosphodiesterase Inhibitors (pharmacology)
  • Pyridines (pharmacology)
  • Thiazoles (pharmacology)

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