Abstract |
Triethyllead chloride and 2,5-hexanedione are known neurotoxicants that apparently work through separate mechanisms. The effect of combined treatment of triethyllead chloride and 2,5-hexanedione for 6 weeks on Fischer 344 rats was investigated. Ten rats were given 0.7 mg/kg triethyllead chloride in a volume of 2 ml/kg by gavage while another group was given 0.5% 2,5-hexanedione in drinking water and vehicle by gavage (2 ml/kg). A third group was given a combination of the two treatments. A fourth group served as controls and was given vehicle by gavage. 2,5-Hexanedione produced a reversible loss of body weight, decreased grip strength, and decreased horizontal motor activity. Triethyllead chloride alone increased hot-plate latencies. Triethyllead chloride and 2,5-hexanedione treated animals recovered 4 weeks after cessation of treatment. Neither treatment alone produced fatalities. In combination (2,5-hexanedione + triethyllead chloride) decreases in body weight appeared additive and there was a 40% mortality by 6 weeks of dosing. Rats given the combined treatment had significant loss of both grip strength and increased hot-plate latencies. Neurobehavioral deficits and neuropathological changes were greater in the combined treatment with 2,5-HD and TEL than when either chemical was used alone; there was little indication of a synergistic interaction between these two types of neurotoxicants.
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Authors | D M Lapadula, H A Tilson, G Campbell, M B Abou-Donia |
Journal | Journal of toxicology and environmental health
(J Toxicol Environ Health)
Vol. 21
Issue 4
Pg. 483-92
( 1987)
ISSN: 0098-4108 [Print] United States |
PMID | 3599091
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Hexanones
- Ketones
- Organometallic Compounds
- triethyllead
- 2,5-hexanedione
- NADH Dehydrogenase
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Topics |
- Administration, Oral
- Animals
- Body Weight
(drug effects)
- Drug Synergism
- Hexanones
(toxicity)
- Ketones
(toxicity)
- Liver
(drug effects, enzymology)
- Male
- Motor Activity
(drug effects)
- NADH Dehydrogenase
(metabolism)
- Organometallic Compounds
(toxicity)
- Rats
- Rats, Inbred F344
- Reaction Time
(drug effects)
- Sciatic Nerve
(drug effects, pathology)
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