[Role of middle mass molecules in the pathogenesis of endotoxicosis in peritonitis].

Abstract

Under examination there were 107 patients with diffuse peritonitis in its different phases. The relationship of clinical manifestations of endotoxicosis and middle mass molecules in the blood was established. One of the causes of the development of endotoxic shock in peritonitis is found to be an instant release of highly toxic substances (middle mass molecules included) from the microcirculation bed. The most effective means of detoxication of the organism include: intraoperative sanitation of the abdominal cavity with the elimination of the infection source, drainage of the small intestine with enterosorption, forced diuresis, hemo- and lymphosorption.

• Authors: I A Eriukhin, V Ia Belyĭ, M D Khanevich, Z A Tupikova, V K Vagner
• Journal: Vestnik khirurgii imeni I. I. Grekova (Vestn Khir Im I I Grek) Vol. 138 Issue 1 Pg. 5-9 (Jan 1987) ISSN: 0042-4625 [Print] Russia (Federation)
• Vernacular Title: Rol' molekul sredneĭ massy v patogeneze éndotoksikoza pri peritonite.
• PMID: 3590536 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Oligopeptides

Topics

• Adsorption
• Adult
• Animals
• Chromatography, Gel
• Combined Modality Therapy
• Dogs
• Humans
• Male
• Middle Aged
• Oligopeptides (blood, toxicity)
• Peritonitis (blood, complications, therapy)
• Spectrophotometry, Ultraviolet
• Tetrahymena (drug effects)
• Toxemia (blood, etiology, therapy)