Abstract |
Substituted 1,5-diaryl-3(4-chlorophenyl)-delta 2-pyrazolines were synthesized and evaluated for anticonvulsant activity. Most pyrazolines (100 mg/kg) provided 20-80% protection against pentylenetetrazol-induced convulsions in mice. All compounds inhibited rat brain mitochondrial monoamine oxidase (MAO) and succinic dehydrogenase (SDH) and exhibited low toxicity as reflected by approximate LD50 values (500 to greater than 1000 mg/kg) in mice.
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Authors | N Soni, K Pande, R Kalsi, T K Gupta, S S Parmar, J P Barthwal |
Journal | Research communications in chemical pathology and pharmacology
(Res Commun Chem Pathol Pharmacol)
Vol. 56
Issue 1
Pg. 129-32
(Apr 1987)
ISSN: 0034-5164 [Print] United States |
PMID | 3589148
(Publication Type: Journal Article)
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Chemical References |
- Anticonvulsants
- Monoamine Oxidase Inhibitors
- Pyrazoles
- Succinate Dehydrogenase
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Topics |
- Animals
- Anticonvulsants
(pharmacology)
- Brain
(enzymology)
- In Vitro Techniques
- Mitochondria
(enzymology)
- Monoamine Oxidase Inhibitors
- Pyrazoles
(pharmacology)
- Rats
- Succinate Dehydrogenase
(antagonists & inhibitors)
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