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Inhibition of rat brain monoamine oxidase and succinic dehydrogenase by anticonvulsant pyrazolines.

Abstract
Substituted 1,5-diaryl-3(4-chlorophenyl)-delta 2-pyrazolines were synthesized and evaluated for anticonvulsant activity. Most pyrazolines (100 mg/kg) provided 20-80% protection against pentylenetetrazol-induced convulsions in mice. All compounds inhibited rat brain mitochondrial monoamine oxidase (MAO) and succinic dehydrogenase (SDH) and exhibited low toxicity as reflected by approximate LD50 values (500 to greater than 1000 mg/kg) in mice.
AuthorsN Soni, K Pande, R Kalsi, T K Gupta, S S Parmar, J P Barthwal
JournalResearch communications in chemical pathology and pharmacology (Res Commun Chem Pathol Pharmacol) Vol. 56 Issue 1 Pg. 129-32 (Apr 1987) ISSN: 0034-5164 [Print] United States
PMID3589148 (Publication Type: Journal Article)
Chemical References
  • Anticonvulsants
  • Monoamine Oxidase Inhibitors
  • Pyrazoles
  • Succinate Dehydrogenase
Topics
  • Animals
  • Anticonvulsants (pharmacology)
  • Brain (enzymology)
  • In Vitro Techniques
  • Mitochondria (enzymology)
  • Monoamine Oxidase Inhibitors
  • Pyrazoles (pharmacology)
  • Rats
  • Succinate Dehydrogenase (antagonists & inhibitors)

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