The effect of tick-borne fever on metabolism and renal clearance of sulfadimidine in goats.

Abstract

The tick-borne fever (TBF) model was used to study the effect of fever on the metabolism of sulfadimidine in goats. During TBF the elimination half-lives were prolonged, and the renal clearance values of sulfadimidine and the majority of its metabolites were markedly diminished compared with those in the uninfected state. During TBF the steady-state levels of the hydroxy metabolites were markedly increased. TBF reduced the extent of hydroxymethylation of the pyrimidine side chain; TBF did not affect acetylation of sulfadimidine. In one goat a progressive accumulation of the metabolites was noticed.

• Authors: J F Nouws, A S Van Miert, H Van Gogh, A D Watson, T B Vree
• Journal: Pharmaceutisch weekblad. Scientific edition (Pharm Weekbl Sci) Vol. 9 Issue 2 Pg. 91-7 (Apr 24 1987) ISSN: 0167-6555 [Print] Netherlands
• PMID: 3588248 (Publication Type: Journal Article)

Chemical References

• Sulfamethazine
• Creatinine

Topics

• Animals
• Chromatography, High Pressure Liquid
• Creatinine (blood)
• Disease Models, Animal
• Ehrlichia
• Goats (metabolism)
• Kinetics
• Rickettsiaceae Infections (metabolism, veterinary)
• Sulfamethazine (adverse effects, metabolism, urine)