HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

An organic selenium and VEGF-conjugated bioinspired coating promotes vascular healing.

Abstract
The introduction of drug-eluting stents (DESs) have yield a significant reduction in the incidence of re-stenosis, however, challenges remain including incomplete healing of the endothelium, inflammatory response and thrombogenesis at the site of vascular wall injury. Here, we developed a novel stent with polyphenol-polyamine surface combining the biological functions of nitric oxide gas and VEGF, selectively promoting the proliferation and migration of endothelial cells while suppressing smooth muscle cells. Compared with bare PLLA stents and traditional DESs, the functionalized stents enhanced vascular healing through remarkable inhibiting intimal hyperplasia and occurrence of thrombosis, accelerating the in-situ endothelium repair. Moreover, it showed a down-regulation of injury vascular inflammation response and reduction of the vessel wall injury in New Zealand Rabbits after 1- and 3-month implantation.
AuthorsBo Zhang, Yumei Qin, Li Yang, Huining Wan, Lu Yuan, Yunbing Wang
JournalBiomaterials (Biomaterials) Vol. 287 Pg. 121654 (Aug 2022) ISSN: 1878-5905 [Electronic] Netherlands
PMID35842980 (Publication Type: Journal Article)
CopyrightCopyright © 2022 Elsevier Ltd. All rights reserved.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: