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[Potentiating effect of disodium salt of 2,6-dimethyl-1,4-dihydropyridine-3,5-bis-carbonyl hydroxyacetic acid on the activity of various antitumor agents].

Abstract
The disodium salt of 2,6-dimethyl-1,4-dihydropyridine-3,5-bis-carbonyl hydroxyacetic acid (I) used in the mg/kg dose decreases the cyclophosphane toxicity in mice and potentiates the cytostatic activity of cyclophosphane, 5-fluorouracil and arabinosyl cytosine against leukemia P388, murine sarcoma 37 and Walker's carcinosarcoma. Administered alone I exhibits no antitumour activity. The potentiation of the antitumour effect of drugs appears independent of the administration schedule. Biochemical evidence indicates that I does not block DNA synthesis in leukemic cells in vitro, but significantly enhances the DNA-blocking effect of cyclophosphane in the same cells in vivo.
AuthorsA A Zidermane, A Zh Dauvarte, A N Kozhukhov, D V Meĭrena, D U Neĭmane
JournalEksperimental'naia onkologiia (Eksp Onkol) Vol. 9 Issue 2 Pg. 50-2 ( 1987) ISSN: 0204-3564 [Print] Ukraine
Vernacular TitlePotentsiiruiushchee deĭstvie dinatrievoĭ soli 2,6-dimetil-1,4-digidropiridin-3,5-bis-karboniloksiuksusnoĭ kisloty na aktivnost' nekotorykh protivoopukholevykh preparatov.
PMID3582240 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Antineoplastic Agents
  • DNA, Neoplasm
  • Dihydropyridines
  • Pyridines
  • 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic hydroxyacetate
Topics
  • Animals
  • Antineoplastic Agents (administration & dosage, pharmacology, toxicity)
  • Cells, Cultured
  • DNA, Neoplasm (biosynthesis)
  • Dihydropyridines
  • Drug Synergism
  • Lethal Dose 50
  • Leukemia P388 (drug therapy, metabolism)
  • Male
  • Mice
  • Neoplasms, Experimental (drug therapy, metabolism)
  • Pyridines (administration & dosage, pharmacology, toxicity)
  • Sarcoma 37 (drug therapy, metabolism)

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