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Lupus profundus in children: treatment with hydroxychloroquine.

Abstract
Discoid lupus erythematosus and lupus profundus, rare in children, are described in two young girls, one with onset at 3 1/2 years of age, the other at 8 years of age. Unusual nodules of the face that ultimately healed with atrophy and hyperpigmentation showed histologic and immunofluorescent confirmation of lupus erythematosus. These patients, the second and third in the English literature to be treated for childhood lupus profundus with antimalarials, responded successfully to hydroxychloroquine. No systemic involvement was found.
AuthorsJ N Fox, M H Klapman, L Rowe
JournalJournal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 16 Issue 4 Pg. 839-44 (Apr 1987) ISSN: 0190-9622 [Print] United States
PMID3571546 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Hydroxychloroquine
Topics
  • Child
  • Female
  • Humans
  • Hydroxychloroquine (adverse effects, therapeutic use)
  • Lupus Erythematosus, Discoid (drug therapy, pathology)
  • Skin (pathology)
  • Skin Pigmentation

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