Abstract |
The effects of the 5-HT2 antagonist pirenperone on temperature preference were observed 1 hr after injection in mice aged 3, 5 and 7 days and at doses of 0.16, 0.48 and 1.6 mg/kg body weight. Although all 3 doses produced significant decreases in preferred temperature at 3 days, only the highest dose had significant effects at ages 5 and 7 days. Analysis of the data suggests that the dose-response relationship depends on age in a way that would be consistent with a shift in the dose-response curve with increasing age.
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Authors | C Goodrich, M Dillehay |
Journal | General pharmacology
(Gen Pharmacol)
Vol. 18
Issue 3
Pg. 225-7
( 1987)
ISSN: 0306-3623 [Print] England |
PMID | 3569849
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Aging
(physiology)
- Animals
- Behavior, Animal
(drug effects)
- Choice Behavior
(drug effects)
- Dose-Response Relationship, Drug
- Mice
- Piperidines
(pharmacology)
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