HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Maturational age affects pirenperone dose-response pattern.

Abstract
The effects of the 5-HT2 antagonist pirenperone on temperature preference were observed 1 hr after injection in mice aged 3, 5 and 7 days and at doses of 0.16, 0.48 and 1.6 mg/kg body weight. Although all 3 doses produced significant decreases in preferred temperature at 3 days, only the highest dose had significant effects at ages 5 and 7 days. Analysis of the data suggests that the dose-response relationship depends on age in a way that would be consistent with a shift in the dose-response curve with increasing age.
AuthorsC Goodrich, M Dillehay
JournalGeneral pharmacology (Gen Pharmacol) Vol. 18 Issue 3 Pg. 225-7 ( 1987) ISSN: 0306-3623 [Print] England
PMID3569849 (Publication Type: Journal Article)
Chemical References
  • Piperidines
  • pirenperone
Topics
  • Aging (physiology)
  • Animals
  • Behavior, Animal (drug effects)
  • Choice Behavior (drug effects)
  • Dose-Response Relationship, Drug
  • Mice
  • Piperidines (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: