Steroid-dependent anosmia.

Abstract

In steroid-dependent anosmia (nasal polyps, inhalant allergy, anosmia), high doses of steroids will temporarily restore the sense of smell, a diagnostic test. Appropriate surgery can then be carried out, followed by low-dose, long-term steroid therapy to maintain the sense of smell. Olfactory biopsy specimens taken during the course of evaluation and treatment show electron-optically normal olfactory receptors, meaning that the probable pathogenesis of the sensory deficit is an obstruction, mechanical and possibly biochemical. Two cases of steroid-dependent anosmia are presented to detail a fully reversible anosmia using state-of-the-art techniques.

• Authors: B W Jafek, D T Moran, P M Eller, J C Rowley 3rd, T B Jafek
• Journal: Archives of otolaryngology--head & neck surgery (Arch Otolaryngol Head Neck Surg) Vol. 113 Issue 5 Pg. 547-9 (May 1987) ISSN: 0886-4470 [Print] United States
• PMID: 3566932 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Adrenal Cortex Hormones

Topics

• Adrenal Cortex Hormones (therapeutic use)
• Combined Modality Therapy
• Ethmoid Sinus (surgery)
• Humans
• Male
• Middle Aged
• Olfaction Disorders (pathology, therapy)
• Sphenoid Sinus (surgery)