Reduced concentrations and increased metabolism of biogenic amines in a single case of Rett-syndrome: a postmortem brain study.

Abstract

Preliminary data of a postmortem brain study in a single case with Rett-syndrome compared to a single control case show a severe reduction of dopamine (DA), noradrenaline (NA), and serotonin (5-HT) in most regions studied and in two regions of adrenaline (A). A marked increase in the 3,4-dihydroxyphenyl acetic acid (DOPAC)/DA, homovanillic acid (HVA)/DA, and the 5-hydroxyindole acetic acid (5-HIAA)/5-HT ratios indicates increased metabolism of DA and 5-HT. Also a marked reduction of 3H-spiroperidol-binding in putamen was found. This agrees with the assumption that a defect in maturation processes of central monoaminergic systems could be an underlying cause of Rett-syndrome.

• Authors: T Brücke, E Sofic, W Killian, A Rett, P Riederer
• Journal: Journal of neural transmission (J Neural Transm) Vol. 68 Issue 3-4 Pg. 315-24 ( 1987) Austria
• PMID: 3559543 (Publication Type: Case Reports, Journal Article)

Chemical References

• Biogenic Amines
• Tritium
• Spiperone

Topics

• Biogenic Amines (metabolism)
• Child
• Child, Preschool
• Female
• Humans
• Male
• Mental Disorders (metabolism)
• Nervous System Diseases (metabolism)
• Osmolar Concentration
• Postmortem Changes
• Putamen (metabolism)
• Spiperone (metabolism)
• Syndrome
• Tritium