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Influence of anesthetic regimen on the frequency of seizures after cervical myelography in the dog.

Abstract
We examined the influence of various anesthetic drug combinations on the frequency of seizures in dogs after cervical myelography with metrizamide. Over a 12-month period, 78 dogs admitted to the teaching hospital for cervical myelography were assigned randomly to 1 of 6 anesthetic protocols. Myelography was performed, and the dogs were observed for signs of seizure activity after recovery from anesthesia. The person making the decision as to whether or not a dog had had a seizure was unaware of the anesthetic protocol that had been used. Preanesthetic treatment with pentobarbital (5.0 mg/kg) and maintenance of anesthesia with methoxyflurane significantly reduced the frequency of seizures (P less than 0.05). No reduction in seizure frequency was seen with any anesthetic protocol using halothane as the maintenance agent.
AuthorsP R Gray, R J Indrieri, A C Lippert
JournalJournal of the American Veterinary Medical Association (J Am Vet Med Assoc) Vol. 190 Issue 5 Pg. 527-30 (Mar 01 1987) ISSN: 0003-1488 [Print] United States
PMID3558089 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Metrizamide
Topics
  • Anesthesia, General (adverse effects, veterinary)
  • Animals
  • Dog Diseases (chemically induced)
  • Dogs
  • Metrizamide (adverse effects)
  • Myelography (veterinary)
  • Seizures (chemically induced, veterinary)

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