[S-100 protein in non-pigmented melanocytic and neuro-ectodermal tumors of the conjunctiva].

Abstract

Using an immunoperoxidase method, S-100 protein was localized in 51 nonpigmented or slightly pigmented nevi, eight malignant melanomas, three neurofibromas, and one neurilemmoma of the conjunctiva. Clinico-immunohistochemical correlations are presented. Cells of these neuroectodermal tumors contain S-100 protein. Epithelial invaginations arising from the conjunctival surface and lying between melanocytes are S-100 protein-negative. This facilitates the differential diagnosis of particularly amelanotic lesions of the conjunctiva. Immunohistochemical identification of the S-100 protein represents an improvement in current histochemical differential diagnosis of these tumors.

• Authors: L Holbach, C Hofmann
• Journal: Klinische Monatsblatter fur Augenheilkunde (Klin Monbl Augenheilkd) Vol. 190 Issue 2 Pg. 105-8 (Feb 1987) ISSN: 0023-2165 [Print] Germany
• Vernacular Title: S-100 Protein in nicht-pigmentierten melanozytären und neuroektodermalen Tumoren der Konjunktiva.
• PMID: 3553717 (Publication Type: English Abstract, Journal Article)

Chemical References

• S100 Proteins

Topics

• Conjunctiva (pathology)
• Conjunctival Neoplasms (pathology)
• Diagnosis, Differential
• Humans
• Immunoenzyme Techniques
• Melanoma (pathology)
• Neurilemmoma (pathology)
• Neurofibroma (pathology)
• S100 Proteins (metabolism)