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Vitamin E and the nervous system.

Abstract
There is increasing evidence that vitamin E is essential for normal neurological function. In abetalipoproteinemia, which is the most severe deficiency state known in man, development of the associated spinocerebellar syndrome can be prevented by early vitamin E therapy. A neurological disorder similar to that seen in abetalipoproteinemia, comprising progressive ataxia, hyporeflexia, and proprioceptive loss, has been described in children and adults with chronic fat malabsorption and vitamin E deficiency. The neuropathological changes in such patients resemble those seen in vitamin E-deficient monkeys. Recent reports suggest that spinocerebellar degeneration may be caused by a selective defect of vitamin E absorption without other evidence of gastrointestinal disease.
AuthorsA E Harding
JournalCritical reviews in neurobiology (Crit Rev Neurobiol) Vol. 3 Issue 1 Pg. 89-103 ( 1987) ISSN: 0892-0915 [Print] United States
PMID3552452 (Publication Type: Journal Article, Review)
Chemical References
  • Vitamin E
Topics
  • Animals
  • Humans
  • Nervous System (physiopathology)
  • Nervous System Diseases (etiology)
  • Vitamin E (metabolism, therapeutic use)
  • Vitamin E Deficiency (physiopathology)

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