HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Xiaoke, a traditional Chinese treatment for diabetes. Studies in streptozotocin diabetic mice and spontaneously diabetic BB/E rats.

Abstract
Xiaoke tea is consumed as a traditional herbal treatment for diabetes mellitus in China. An aqueous extract of Xiaoke (1 g of dried plant preparation in 64 ml of water), supplied ad lib in place of drinking water during the induction and development of streptozotocin diabetes in mice, reduced (about 30%) plasma glucose concentrations by 25 days. The polydipsia and hyperphagia of the streptozotocin diabetic mice were also reduced by Xiaoke, and the effects lapsed after treatment was withdrawn. Xiaoke did not significantly alter plasma insulin concentrations. Consumption of the Xiaoke extract by insulin-treated diabetic BB/E Wistar rats did not affect glycaemic control or body wt. When insulin treatment was reduced and discontinued, Xiaoke failed to prevent the progression of severe hyperglycaemia and weight loss. The results suggest that the slowly generated antihyperglycaemic effect of Xiaoke in streptozotocin diabetic mice may involve an extrapancreatic effect on food intake, glucose production or glucose clearance. However, as evidenced in BB/E rats, Xiaoke does not substitute for insulin in the absence of endogenous insulin secretion.
AuthorsC J Bailey, D Brown, W Smith, A J Bone
JournalDiabetes research (Edinburgh, Scotland) (Diabetes Res) Vol. 4 Issue 1 Pg. 15-8 (Jan 1987) ISSN: 0265-5985 [Print] Scotland
PMID3552362 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Blood Glucose
  • Hypoglycemic Agents
  • Insulin
  • Plant Extracts
Topics
  • Animals
  • Blood Glucose (analysis)
  • Diabetes Mellitus, Experimental (drug therapy)
  • Hypoglycemic Agents (therapeutic use)
  • Insulin (blood)
  • Male
  • Medicine, Chinese Traditional
  • Medicine, East Asian Traditional
  • Mice
  • Plant Extracts (therapeutic use)
  • Plants, Medicinal
  • Rats
  • Rats, Inbred Strains

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: