Digoxin for converting recent-onset atrial fibrillation to sinus rhythm. A randomized, double-blinded trial.

Abstract

STUDY OBJECTIVE:

to determine whether digoxin is effective in converting atrial fibrillation of recent onset to normal sinus rhythm.

DESIGN:

randomized, double-blinded, placebo-controlled trial with a maximum 18-hour treatment period.

SETTING:

emergency room and medical floors of a non-referral city hospital.

PATIENTS:

consecutive sample of 36 patients with atrial fibrillation of 7 days' duration or less, not on digitalis glycoside or anti-arrhythmic agents, with ventricular rate between 85 to 175 beats/min, without evidence of heart failure, acute myocardial infarction, unstable angina, preexcitation syndrome, thyrotoxicosis, hypokalemia, renal impairment, or severe metabolic disturbances.

INTERVENTIONS:

digoxin solution in capsules or identical placebo, given in doses of 0.6, 0.4, 0.2, and 0.2 mg, at 0, 4, 8, and 14 hours, respectively, or until conversion to sinus rhythm, whichever occurred first. Continuous electrocardiographic recording by Holter monitor.

MEASUREMENTS AND MAIN RESULTS:

nine of eighteen patients receiving digoxin and 8 of 18 receiving placebo had a return to sinus rhythm within 18 hours of study entry (95% confidence interval for the difference in proportions, -11% to 22%). Mean time to conversion was 5.1 hours in the digoxin group and 3.3 in the placebo group (95% Cl, -3.6 to 7.0 hours).

CONCLUSIONS:

spontaneous reversion to sinus rhythm is common in patients with atrial fibrillation of recent onset. Digitalization was not shown to affect the likelihood of reversion to sinus rhythm, and thus cannot be recommended for this purpose in patients with atrial fibrillation.

• Authors: R H Falk, A A Knowlton, S A Bernard, N E Gotlieb, N J Battinelli
• Journal: Annals of internal medicine (Ann Intern Med) Vol. 106 Issue 4 Pg. 503-6 (Apr 1987) ISSN: 0003-4819 [Print] United States
• PMID: 3548521 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Digoxin

Topics

• Atrial Fibrillation (drug therapy, physiopathology)
• Clinical Trials as Topic
• Digoxin (blood, therapeutic use)
• Double-Blind Method
• Heart Rate (drug effects)
• Humans
• Middle Aged
• Myocardial Contraction (drug effects)
• Random Allocation
• Stroke Volume (drug effects)