[Pharyngeal viral population in 3- to 6-year-old children before and after influenza immunization using the NIVGRIP vaccine administered orally].

Abstract

Immunofluorescence techniques were used to investigate the incidence of viral antigens in exfoliated pharyngeal cells collected from 94 3-6-year-old children living in a collectivity, vaccinated by oral route with NIVGRIP inactivated influenza vaccine. The vaccination resulted in a significant decrease of IF-positive subjects from 80% before to 39% after immunization, indicating a fall in the virus carriage level. The percentage of children in which two or more viral antigens were found also decreased from 72% to 33%. As regards the incidence of different viruses, the complete disappearance of influenza antigens and a marked decrease of the other investigated viral agents were recorded.

• Authors: C Pârvu, A Petrescu, V Coban
• Journal: Virologie (Virologie) 1986 Oct-Dec Vol. 37 Issue 4 Pg. 263-7 ISSN: 0253-181X [Print] Romania
• Vernacular Title: Etude de la population virale du pharynx chez des enfants âgés de 3 à 6 ans avant et après l'immunisation contre la grippe à l'aide du vaccin NIVGRIP administré par voie orale.
• PMID: 3548031 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antigens, Viral
• Influenza Vaccines
• Vaccines, Attenuated

Topics

• Administration, Oral
• Antigens, Viral (analysis)
• Child
• Child, Preschool
• Fluorescent Antibody Technique
• Humans
• Immunization
• Influenza A virus (immunology, isolation & purification)
• Influenza Vaccines (administration & dosage, immunology)
• Influenza, Human (microbiology, prevention & control)
• Pharynx (microbiology)
• Vaccines, Attenuated (administration & dosage, immunology)