Protective immunity induced by outer membrane proteins of Salmonella typhimurium in mice.

Abstract

Outer membrane proteins (OMP) extracted from both smooth (C5) and rough (Rb2) strains of Salmonella typhimurium were able to induce protective immunity to salmonellosis. The OMP-induced protection lasted for at least 6 months. The antibody level was estimated by passive hemagglutination. In the C5 OMP-immunized mice, antibodies to both proteins and lipopolysaccharide were detected. On the other hand, in the Rb2 OMP-immunized mice, antiprotein but not antilipopolysaccharide antibodies were detected. Delayed-type hypersensitivity appeared as early as the second week after immunization with OMP and persisted through the fourth week.

• Authors: V Udhayakumar, V R Muthukkaruppan
• Journal: Infection and immunity (Infect Immun) Vol. 55 Issue 3 Pg. 816-21 (Mar 1987) ISSN: 0019-9567 [Print] United States
• PMID: 3546142 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Bacterial
• Bacterial Outer Membrane Proteins
• Bacterial Vaccines
• Lipopolysaccharides

Topics

• Animals
• Antibodies, Bacterial (biosynthesis)
• Bacterial Outer Membrane Proteins (immunology, isolation & purification)
• Bacterial Vaccines (immunology, isolation & purification)
• Immunity, Cellular
• Immunization
• Lipopolysaccharides (immunology)
• Mice
• Mice, Inbred BALB C
• Salmonella Infections, Animal (microbiology, prevention & control)
• Salmonella typhimurium (analysis, immunology, isolation & purification)