[Serial testing of anti-arrhythmia preparations using the intracardiac electrophysiological study of patients with reciprocal paroxysmal tachycardias].

Abstract

Diagnostic investigation of 36 patients with reciprocal paroxysmal tachycardias, using intracardiac electrophysiologic tests, revealed supraventricular paroxysmal tachycardia in 29 patients, and ventricular paroxysmal tachycardia in 7. Serial trials of antiarrhythmic drugs in acute experiments with simultaneous electrophysiologic studies made possible efficient medication in 80% of the patients. A high correlation was demonstrated between the results of acute antiarrhythmic drug tests and subsequent long-term treatment. Ritmilen proved particularly effective in patients with paroxysmal tachycardias in the presence of the ventricular pre-excitation syndrome, while cordarone and etmozin were most effective antiarrhythmic drugs for reciprocal ventricular tachycardias. No preferential antiarrhythmic agent could be established for patients with reciprocal paroxysmal tachycardias due to double atrioventricular conduction.

• Authors: V A Sulimov, V I Makolkin, A L Syrkin, G M Papakin, V V Pavlov
• Journal: Kardiologiia (Kardiologiia) Vol. 26 Issue 11 Pg. 30-5 (Nov 1986) ISSN: 0022-9040 [Print] Russia (Federation)
• Vernacular Title: Seriĭnoe testirovanie antiaritmicheskikh preparatov s pomoshch'iu vnutriserdechnogo élektrofiziologicheskogo issledovaniia u bol'nykh s retsiproknymi paroksizmal'nymi takhikardiiami.
• PMID: 3543458 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• Anti-Arrhythmia Agents

Topics

• Adolescent
• Adult
• Anti-Arrhythmia Agents (therapeutic use)
• Cardiac Catheterization
• Cardiac Pacing, Artificial
• Clinical Trials as Topic (methods)
• Female
• Heart (drug effects, physiopathology)
• Humans
• Male
• Middle Aged
• Tachycardia, Paroxysmal (drug therapy, etiology, physiopathology)
• Wolff-Parkinson-White Syndrome (drug therapy, physiopathology)