HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Double-blind therapeutic evaluation of fluspirilene compared with fluphenazine decanoate in chronic schizophrenics.

Abstract
Fifty chronic schizophrenics were randomly assigned to a 16-week treatment either with fluspirilene or with fluphenazine decanoate. The aim of the study was to compare the antipsychotic action and the side effects of the two neuroleptics. Fluphenazine decanoate caused more side effects and the difference between the two groups was statistically significant in the items tremor, severe extrapyramidal effects and parkinsonism. More patients in the fluspirilene group (nine patients) compared with only three in the fluphenazine decanoate group remained free of side effects during the whole trial. Judged from the BPRS fluspirilene proved an equally potent neuroleptic with fluphenazine decanoate although statistically significant improvement has been obtained in more items of the scale in the fluspirilene group. The improvement in the NOSIE-30 was much more clear in the fluspirilene group. Although Clinical Global Impressions of the investigators and the nursing personnel favored fluspirilene, the differences between the two groups were not statistically significant.
AuthorsH Frangos, N P Zissis, I Leontopoulos, N Diamantas, S Tsitouridis, I Gavriil, K Tsolis
JournalActa psychiatrica Scandinavica (Acta Psychiatr Scand) Vol. 57 Issue 5 Pg. 436-46 (May 1978) ISSN: 0001-690X [Print] United States
PMID354331 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Spiro Compounds
  • Fluspirilene
  • Fluphenazine
Topics
  • Adult
  • Clinical Trials as Topic
  • Double-Blind Method
  • Drug Evaluation
  • Female
  • Fluphenazine (administration & dosage, adverse effects, therapeutic use)
  • Fluspirilene (administration & dosage, adverse effects, therapeutic use)
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease, Secondary (chemically induced)
  • Schizophrenia (drug therapy)
  • Sleep Wake Disorders (chemically induced)
  • Spiro Compounds (therapeutic use)
  • Tremor (chemically induced)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: