The response of patients with organic hypothalamic-pituitary disease to pulsatile gonadotropin-releasing hormone therapy.

Abstract

Treatment with pulsatile gonadotropin-releasing hormone (GnRH) therapy has been attempted in 13 women and 5 men with hypogonadotropic hypogonadism caused by structural lesions of the hypothalamic-pituitary axis. Ten patients responded to treatment with induction of ovulation or spermatogenesis. Of these subjects, seven had primary suprasellar lesions, and one had an apparently empty pituitary fossa on reconstructive computerized tomographic scanning. The eight patients who failed to respond to treatment all had extensive intrafossa damage, as a result of either surgery, irradiation, or infarction. Pulsatile GnRH therapy is not effective in patients with extensive intrafossa lesions.

• Authors: D V Morris, N A Abdulwahid, A Armar, H S Jacobs
• Journal: Fertility and sterility (Fertil Steril) Vol. 47 Issue 1 Pg. 54-9 (Jan 1987) ISSN: 0015-0282 [Print] United States
• PMID: 3539644 (Publication Type: Journal Article)

Chemical References

• Pituitary Hormone-Releasing Hormones

Topics

• Female
• Humans
• Hypothalamic Diseases (complications, drug therapy)
• Infertility, Female (drug therapy, etiology)
• Infertility, Male (drug therapy, etiology)
• Infusion Pumps
• Male
• Pituitary Diseases (complications, drug therapy)
• Pituitary Hormone-Releasing Hormones (administration & dosage, therapeutic use)