Effects of captopril and bradykinin on arterial pressure in rats with mestranol-induced hypertension.

Abstract

Hypertension was produced in 20 female rats by the oral administration of mestranol for 6 months; 20 control rats were not given mestranol during this time. The i.v. infusion of the angiotensin converting enzyme inhibitor, captopril, into 10 conscious mestranol-treated rats reduced mean arterial pressure from 139 +/- 2 (SEM) to 130 +/- 2 mm Hg (P less than 0.01); mean arterial pressure in 10 conscious control rats averaged 123 +/- 3 mm Hg, and was not significantly changed during captopril infusion. Injections of bradykinin at 0.1, 0.3, and 1.0 microgram/100 gm body weight decreased mean arterial pressure significantly more in 10 mestranol-treated rats than in 10 control rats. These results suggest that the ability of captopril to lower arterial pressure in rats with mestranol-induced hypertension may be due, at least in part, to the action of captopril to enhance bradykinin.

• Authors: J A Johnson, D E Dostal
• Journal: Contraception (Contraception) Vol. 34 Issue 3 Pg. 303-10 (Sep 1986) ISSN: 0010-7824 [Print] United States
• PMID: 3539511 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Angiotensin I
• Captopril
• Mestranol
• Bradykinin

Topics

• Angiotensin I (pharmacology)
• Animals
• Blood Pressure (drug effects)
• Bradykinin (pharmacology)
• Captopril (pharmacology)
• Female
• Hypertension (chemically induced, physiopathology)
• Mestranol (toxicity)
• Rats
• Rats, Inbred Strains
• Renin-Angiotensin System