A long-term evaluation of the treatment of osteoarthritis.

In a study of the long-term safety and efficacy of piroxicam (20 mg daily) in the treatment of osteoarthritis, 30 female patients with a mean duration of more than seven years of treatment were evaluated. Despite having had poor or no response with other drug therapies, in the majority of cases in which piroxicam was used half of the patients (15 of 30) reported feeling very good or good at their last visit, 13 said they felt fair, and only two reported feeling poor or very poor in terms of their sense of well-being. The incidence of adverse events was somewhat less than one event per patient year of exposure, and 94 percent of adverse events were mild or moderate. Laboratory measurements of drug safety did not reveal any evidence of renal, hepatic, or hematologic toxicity. It is significant that patients were willing to commit themselves to long-term piroxicam therapy for at least five years after an initial trial and that they preferred to continue taking the drug rather than switch to alternative forms of therapy.
AuthorsT M Zizic, J D Sutton, M B Stevens
JournalThe American journal of medicine (Am J Med) Vol. 81 Issue 5B Pg. 29-35 (Nov 28 1986) ISSN: 0002-9343 [Print] UNITED STATES
PMID3538868 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Piroxicam
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Anti-Inflammatory Agents, Non-Steroidal (adverse effects, therapeutic use)
  • Attitude to Health
  • Clinical Trials as Topic
  • Female
  • Humans
  • Joints (physiopathology)
  • Longitudinal Studies
  • Middle Aged
  • Osteoarthritis (drug therapy, physiopathology)
  • Pain (physiopathology)
  • Piroxicam (adverse effects, therapeutic use)
  • Sex Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: