Therapeutic response to lovastatin (mevinolin) in nonfamilial hypercholesterolemia. A multicenter study. The Lovastatin Study Group II.

Abstract

Lovastatin (mevinolin), a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, was investigated in a double-blind, placebo-controlled multicenter study of 101 patients with nonfamilial primary hypercholesterolemia. Dosages varied from 10 to 80 mg/d in single or divided doses. Patients receiving 40 mg twice a day experienced mean total and low-density lipoprotein cholesterol reductions of 32% and 39%, respectively. High-density lipoprotein cholesterol levels tended to rise slightly and plasma triglyceride levels were moderately decreased. Adverse effects attributable to lovastatin were infrequent and no patient was withdrawn from therapy. In this study, lovastatin was a well tolerated and effective agent for the treatment of nonfamilial hypercholesterolemia.

• Journal: JAMA (JAMA) Vol. 256 Issue 20 Pg. 2829-34 (Nov 28 1986) ISSN: 0098-7484 [Print] United States
• PMID: 3534333 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Anticholesteremic Agents
• Apolipoproteins
• Lipids
• Naphthalenes
• Lovastatin

Topics

• Anticholesteremic Agents (adverse effects, therapeutic use)
• Apolipoproteins (blood)
• Clinical Trials as Topic
• Dose-Response Relationship, Drug
• Double-Blind Method
• Drug Administration Schedule
• Female
• Humans
• Hypercholesterolemia (drug therapy)
• Lipids (blood)
• Lovastatin
• Male
• Middle Aged
• Naphthalenes (adverse effects, therapeutic use)