Abstract |
The National Cancer Institute of Canada Clinical Trials Group conducted a phase II study of lonidamine, given in an escalating oral daily schedule in patients with measurable advanced renal cell carcinoma. Two responses were seen in 25 evaluable patients. Toxicity was mild or moderate in most patients and included myalgia, nausea, vomiting, somnolence, and testicular pain. Lonidamine was not myelosuppressive. This agent had only minimal activity against renal cell carcinoma when given in this oral schedule.
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Authors | B H Weinerman, E A Eisenhauer, J G Besner, C M Coppin, D Stewart, P R Band |
Journal | Cancer treatment reports
(Cancer Treat Rep)
Vol. 70
Issue 6
Pg. 751-4
(Jun 1986)
ISSN: 0361-5960 [Print] United States |
PMID | 3524824
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Indazoles
- Pyrazoles
- Testosterone
- lonidamine
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Topics |
- Adult
- Aged
- Antineoplastic Agents
(adverse effects, therapeutic use)
- Carcinoma, Renal Cell
(blood, drug therapy)
- Clinical Trials as Topic
- Drug Administration Schedule
- Drug Evaluation
- Female
- Humans
- Indazoles
(adverse effects, blood, therapeutic use)
- Kidney Neoplasms
(blood, drug therapy)
- Male
- Middle Aged
- Nausea
(chemically induced)
- Pain
(chemically induced)
- Pyrazoles
(therapeutic use)
- Testis
(drug effects, metabolism)
- Testosterone
(blood)
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