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Oestriol with oestradiol verses oestradiol alone: a comparison of endometrial, symptomatic and psychological effects.

Abstract
In a prospective, double-blind, randomized, cross-over trial, the effects of oral oestradiol, 2 mg daily, on the endometrial histology, frequency and severity of vaginal bleeding, and the symptomatic and psychological status of postmenopausal women were compared with those of oral oestradiol, 2 mg daily, plus oestriol, 1 mg daily. Both therapies were prescribed for 3 months on a cyclical basis. The addition of oestriol to oestradiol did not modify the endometrial response. The prevalence of proliferative/hyperplastic endometrium (64%: 9 of 14 biopsies) was similar after both treatments and there were no significant differences in either the frequency or heaviness of vaginal bleeding. Both therapies significantly reduced hot flushes, night sweats and vaginal dryness: no significant differences in effect on the symptomatic and psychological status were recorded. The addition of 1 mg of oestriol to 2 mg of oestradiol did not confer any benefit and the value of such an addition is challenged.
AuthorsM L Padwick, N C Siddle, G Lane, J A Endacott, H Cooper, J Pryse-Davies, M I Whitehead
JournalBritish journal of obstetrics and gynaecology (Br J Obstet Gynaecol) Vol. 93 Issue 6 Pg. 606-12 (Jun 1986) ISSN: 0306-5456 [Print] England
PMID3524665 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Drug Combinations
  • Estradiol
  • Estriol
Topics
  • Adult
  • Clinical Trials as Topic
  • Double-Blind Method
  • Drug Combinations
  • Emotions (drug effects)
  • Endometrium (anatomy & histology, drug effects)
  • Estradiol (therapeutic use)
  • Estriol (therapeutic use)
  • Female
  • Humans
  • Menopause (drug effects)
  • Middle Aged
  • Random Allocation
  • Uterine Hemorrhage (etiology)

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