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The efficacy of ketotifen in a controlled double-blind food challenge study in patients with food allergy.

Abstract
The effectiveness of oral ketotifen was compared with that of placebo in 26 patients with food allergy in a randomized, double-blind parallel study. Patients were selected on the basis of food allergy as established by history, clinical improvement after an exclusion diet, and reappearance of the symptoms after a challenge with the food. Thirteen patients were given ketotifen and 13, placebo. Ketotifen or placebo were administered twice daily for 1 month after the first oral provocation test and the last dose was given 12 hours before the second oral provocation test. Ketotifen protected patients (7/13) significantly more than placebo (2/13; P less than .05). The results of this study suggest that ketotifen may be useful for some patients with food allergy.
AuthorsA L Boner, C Richelli, I Antolini, C Vibelli, L Andri
JournalAnnals of allergy (Ann Allergy) Vol. 57 Issue 1 Pg. 61-4 (Jul 1986) ISSN: 0003-4738 [Print] United States
PMID3524320 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Placebos
  • Ketotifen
Topics
  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Clinical Trials as Topic
  • Double-Blind Method
  • Female
  • Food Hypersensitivity (drug therapy)
  • Humans
  • Infant
  • Ketotifen (therapeutic use)
  • Male
  • Middle Aged
  • Placebos

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