Marrow transplantation in preleukemia.

Abstract

Preleukemia has generally been treated by palliative measures. Several reports have indicated that cytarabine given as low-dose infusion results in responses, albeit short lived, in a fraction of patients. We have shown recently that marrow transplantation offers a useful alternative. Twelve patients have been treated and followed for a minimum of 1 year. Three were conditioned with cyclophosphamide (CY) only, and all died with recurrent or persistent disease. Nine were conditioned with CY and total-body irradiation; all but 1 had lasting engraftment, and 7 are surviving, free of disease, 16-36 (median 27) months after transplantation. These data show that marrow transplantation can provide successful therapy for preleukemia.

• Authors: H J Deeg
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 76 Issue 6 Pg. 1329-32 (Jun 1986) ISSN: 0027-8874 [Print] United States
• PMID: 3520076 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Cyclophosphamide

Topics

• Adolescent
• Adult
• Bone Marrow Transplantation
• Child
• Child, Preschool
• Cyclophosphamide (therapeutic use)
• Female
• Humans
• Male
• Preleukemia (therapy)
• Transplantation, Homologous
• Whole-Body Irradiation