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Calcium uptake during insulin-aggravated ischemic myocardial contracture in the rat heart.

Abstract
Perfusion of isolated, nondiabetic rat hearts with high concentrations of regular insulin (10 mU/ml) produced earlier onset of myocardial contracture during ischemia than control perfusions without insulin. High insulin concentrations also increased total myocardial calcium content (p less than .001) and myocardial Ca-45 uptake postischemia (p less than .05). Insulin perfusion before ischemia did not enhance calcium uptake. These results support the hypothesis that insulin may increase calcium movement across myocardial cell membranes, which may lead to increased ischemic contracture. Insulin-aggravated myocardial ischemia in cardiothoracic surgery and cardiac resuscitation deserves further investigation.
AuthorsE Pretto, T Schaible, J Scheuer, P Safar, S W Stezoski
JournalCritical care medicine (Crit Care Med) Vol. 14 Issue 6 Pg. 560-2 (Jun 1986) ISSN: 0090-3493 [Print] United States
PMID3519079 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Insulin
  • Calcium
Topics
  • Animals
  • Blood Pressure (drug effects)
  • Calcium (metabolism)
  • Coronary Disease (metabolism, physiopathology)
  • In Vitro Techniques
  • Insulin (toxicity)
  • Male
  • Myocardial Contraction (drug effects)
  • Myocardium (metabolism)
  • Premedication
  • Rats
  • Rats, Inbred Strains

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