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Treatment of depression in chronic cocaine and phencyclidine abuse with desipramine.

Abstract
An open field trial was conducted comparing desipramine and an active placebo in separate populations of chronic cocaine and phencyclidine (PCP) abusers, who discontinued their abuse. Subjects who received desipramine showed a decrease in depressive symptoms after a 20-40 day period regardless of whether they abused PCP or cocaine.
AuthorsA J Giannini, D A Malone, M C Giannini, W A Price, R H Loiselle
JournalJournal of clinical pharmacology (J Clin Pharmacol) Vol. 26 Issue 3 Pg. 211-4 (Mar 1986) ISSN: 0091-2700 [Print] England
PMID3514688 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
Chemical References
  • Placebos
  • Cocaine
  • Phencyclidine
  • Desipramine
Topics
  • Adult
  • Clinical Trials as Topic
  • Cocaine
  • Depression (drug therapy, etiology)
  • Desipramine (therapeutic use)
  • Humans
  • Male
  • Phencyclidine
  • Placebos
  • Substance Withdrawal Syndrome
  • Substance-Related Disorders (complications)

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