Abstract |
Rabbits developed chancre immunity 5.0 to 7.5 weeks after intradermal infection with 10(3) Treponema pallidum (Nichols). The serological response against T. pallidum antigen during this 2.5-week period was examined by Western immunoblotting. Sera from rabbits infected for 5.0 weeks contained antibodies against 7 of 13 major T. pallidum immunogens, with strongest binding detected against a polypeptide of Mr 47,000. By 7.5 weeks of infection, syphilitic rabbit sera recognized 10 of 13 antigens; the most evident increase in serological reactivity was directed against a polypeptide of Mr 45,000, suggesting that the development of a strong serological response against this polypeptide correlated with the onset of chancre immunity.
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Authors | R A Strugnell, W F Williams, L Drummond, J S Pedersen, B H Toh, S Faine |
Journal | Infection and immunity
(Infect Immun)
Vol. 51
Issue 3
Pg. 957-60
(Mar 1986)
ISSN: 0019-9567 [Print] United States |
PMID | 3512444
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Bacterial
- Bacterial Proteins
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Topics |
- Animals
- Antibodies, Bacterial
(immunology)
- Antibody Specificity
- Bacterial Proteins
(immunology)
- Chancre
(immunology)
- Immunity
- Immunosorbent Techniques
- Molecular Weight
- Rabbits
- Syphilis
(immunology)
- Treponema pallidum
(immunology)
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