Third generation cephalosporin antibiotics in surgical practice.

Abstract

The new third generation cephalosporins have a significantly greater spectrum of action against gram-negative bacteria likely to be encountered in surgical infections. This expanded spectrum may permit these drugs to be used in place of combination therapy in patients with polymicrobial infections; however, current evidence does not indicate superior results with these agents over earlier generation choices for surgical prophylaxis. The toxicity profile of these drugs warrants close monitoring for serious complications.

• Authors: D E Fry
• Journal: American journal of surgery (Am J Surg) Vol. 151 Issue 2 Pg. 306-13 (Feb 1986) ISSN: 0002-9610 [Print] United States
• PMID: 3511763 (Publication Type: Clinical Trial, Journal Article, Review)

Chemical References

• Cephalosporins

Topics

• Bacteria (drug effects)
• Bacterial Infections (drug therapy)
• Central Nervous System Diseases (drug therapy)
• Cephalosporins (adverse effects, metabolism, pharmacology, therapeutic use)
• Chemical Phenomena
• Chemistry
• Cholecystitis (drug therapy)
• Clinical Trials as Topic
• Cross Infection (drug therapy)
• Female
• Genital Diseases, Female (drug therapy)
• Humans
• Premedication
• Surgical Wound Infection (prevention & control)