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Cefoxitin versus clindamycin and gentamicin in the treatment of postcesarean section infections.

Abstract
Cefoxitin, a cefamycin derivative, has demonstrated activity against a broad spectrum of aerobic and anaerobic bacterial pathogens. The efficacy and safety of cefoxitin were compared with that of the combination of clindamycin and gentamicin in the treatment of postcesarean section infection. Ninety-eight patients were evaluated. Cefoxitin cured 36 of 48 patients (75%); clindamycin/gentamicin cured 38 of 50 (76%) (P greater than .05). Febrile degree hours and length of hospital stay did not differ between the two study groups. No patient experienced abscess formation or septic pelvic thrombophlebitis. Both therapies were well tolerated. In the authors' experience, cefoxitin as a single agent was as effective in the treatment of postoperative pelvic infection as the combination of clindamycin and gentamicin.
AuthorsG Herman, A W Cohen, G H Talbot, R Coghlan, P Faidley-Mangen, R R MacGregor
JournalObstetrics and gynecology (Obstet Gynecol) Vol. 67 Issue 3 Pg. 371-6 (Mar 1986) ISSN: 0029-7844 [Print] United States
PMID3511419 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Gentamicins
  • Clindamycin
  • Cefoxitin
Topics
  • Adult
  • Bacterial Infections (drug therapy)
  • Cefoxitin (therapeutic use)
  • Cesarean Section
  • Clindamycin (administration & dosage)
  • Clinical Trials as Topic
  • Drug Therapy, Combination
  • Female
  • Follow-Up Studies
  • Gentamicins (administration & dosage)
  • Humans
  • Postoperative Complications (drug therapy)
  • Pregnancy
  • Prospective Studies
  • Random Allocation
  • Surgical Wound Infection (drug therapy)

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