HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Torsion dystonia: a double-blind, prospective trial of high-dosage trihexyphenidyl.

Abstract
We studied trihexyphenidyl in the treatment of torsion dystonia in a prospective, double-blind crossover protocol. Thirty-one patients completed the protocol. Twenty-two (71%) had a clinically significant response. After a mean follow-up of 2.4 years, 68% of patients continued to take trihexyphenidyl, and 42% continued to show a considerable or dramatic benefit. The 30-mg dose used was generally well tolerated. High-dosage trihexyphenidyl therapy is effective in the management of torsion dystonia.
AuthorsR E Burke, S Fahn, C D Marsden
JournalNeurology (Neurology) Vol. 36 Issue 2 Pg. 160-4 (Feb 1986) ISSN: 0028-3878 [Print] United States
PMID3511401 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Trihexyphenidyl
Topics
  • Adolescent
  • Adult
  • Child
  • Clinical Trials as Topic
  • Double-Blind Method
  • Dystonia Musculorum Deformans (drug therapy)
  • Female
  • Humans
  • Male
  • Movement (drug effects)
  • Prospective Studies
  • Random Allocation
  • Trihexyphenidyl (administration & dosage, adverse effects, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: